CollGel™ SERIES BIOINK
3D BIOPRINTING FOR TISSUE ENGINEERING
CUSTOMISABLE STIFFNESS
CollGel-01 enables precise control over collagen concentration, allowing researchers to fine-tune mechanical strength, viscosity, and rheological behaviour. This tunable formulation ensures scaffolds closely replicate the biomechanical properties of native extracellular matrices (ECM), making it highly adaptable for a wide range of tissue engineering applications.
With its adjustable stiffness and optimised printability, CollGel-01 provides the versatility needed to support diverse bioprinting techniques and advance regenerative research.
TAILORED FORMULATION VERSATILITY
CollGel-01 is designed for flexible reconstitution with PBS, culture medium, or water, ensuring compatibility across a wide range of bioprinting and tissue engineering applications. Its ECM-mimetic composition allows seamless integration with gelatin, hyaluronic acid, and methacrylated polymers, enabling the fabrication of hybrid scaffolds with enhanced mechanical properties and biofunctionality.
By optimising cell behaviour, scaffold integration, and tissue development, CollGel-01 serves as a highly adaptable bioink, supporting advanced biofabrication strategies in tissue engineering.
“Physiologically Tunable Collagen Bioink: CollGel-01 enables precise control over ECM concentration and fibre alignment, allowing the fabrication of artificial tissues that closely match native biomechanical properties. By adjusting collagen stiffness and structure, researchers can replicate soft tissues (e.g., brain, lung) at lower concentrations and stiffer tissues (e.g., cartilage, bone) at higher concentrations. This biomimetic approach enhances biofunctionality, guiding cellular behaviour and advancing next-generation regenerative medicine.”
Bioink: 6% COLLGEL-01 [1X PBS]
Without Cell-Laden
Extrusion Printing [Directly]
ADAPTBILITY TO 3D BIOPRITNING
CollGel-01 ensures high structural fidelity, enabling the fabrication of precise scaffold geometries for advanced bioprinting applications.
At physiological ionic strength, CollGel-01 undergoes controlled self-assembly, promoting fibrillogenesis and enhanced cross-linking. This natural structuring process improves printability and mechanical integrity, optimising CollGel-01 for diverse bioprinting techniques.
• At >5% collagen concentration, it supports direct writing in air, eliminating the need for support gels, making it ideal for freeform bioprinting.
• At <3% collagen concentration, it allows for direct injection or seamless integration with GelMA, expanding its versatility for SLA and inkjet bioprinting in tissue engineering and biomaterial hybridisation.
BIOCOMPATIBILITY AND ECM MIMICRY
CollGel-01 is formulated with medical-grade atelocollagen derived from porcine Type I collagen, ensuring exceptional purity and biocompatibility. Its neutralised, highly purified composition closely mimics the native extracellular matrix (ECM), creating an optimal environment for cell adhesion, proliferation, and differentiation—all essential for functional tissue development.
Designed for live-cell encapsulation, CollGel-01 ensures uniform cell distribution and maintains high cell viability within the scaffold. By faithfully replicating the biochemical and structural properties of physiological ECM, it enhances cellular interactions and tissue maturation, establishing itself as a versatile platform for advanced tissue engineering and regenerative medicine applications.
Bioink: 6% COLLGEL-01 [1X PBS]
Cell-Laden [Human Fibroblast]
Day 7 L/D
Extrusion Printing [Directly]
CollGel™ SERIES BIOINK
IN VITRO MODEL FOR DRUG DISCOVERY
TUNABLE BIOINK PROPERTIES
CollGel-01 offers adjustable stiffness and viscosity, making it highly versatile for in vitro models, from 2D monolayer cultures to organoid formation and complex 3D bioprinted constructs. These properties are modulated by collagen concentration, allowing researchers to replicate the mechanical cues of native tissues and tailor bioinks for specific experimental needs.
This adaptability is essential for creating physiologically relevant microenvironments, optimised for cell adhesion, proliferation, and stem cell differentiation, enhancing predictive drug screening and disease modelling.
Bioink: 3% COLLGEL-01 [1X PBS]
With Cell-Laden [Human Epithelial Cells]
Day 28
Extrusion Printing [Directly]
NATURAL GELATION AND THERMAL STABILITY
CollGel-01 undergoes fibrillar network formation under physiological conditions, self-assembling at neutral pH with controlled collagen concentration and ionic strength. This natural gelation process eliminates the need for chemical crosslinkers, ensuring a biocompatible and physiologically relevant extracellular matrix (ECM) environment suitable for both bioprinting and injectable applications.
Upon incubation at 37°C, the fibrillar network is further reinforced, enhancing mechanical stability and ensuring long-term structural support during cell culture. This maturation process allows CollGel-01 to maintain its structure and biofunctionality over extended cultivation periods, making it an ideal bioink for tissue engineering and regenerative applications.
BATCH CONSISTENCY
With the Inktegration™ design, CollGel™ Series bioinks are pre-filled in a sterile, sealed format, ensuring batch-to-batch consistency and eliminating variability in ECM-derived hydrogels. Their high-purity collagen, processed under endotoxin-free conditions, preserves bioink integrity and cellular compatibility.
Manufactured in a GMP-compliant facility, CollGel™ Series undergoes strict quality control, ensuring sterility, reliability, and reproducible performance. This ready-to-use format streamlines high-throughput screening, toxicity studies, and regenerative research, delivering consistent results with every batch.
CollGel™ SERIES BIOINK
REGENERATIVE MEDICINE AND CELL THERAPY
For Research Labs Only – Not Quite Clinic-Ready
The CollGel™ Series bioinks are strictly for research use only (RUO) — so, while they’re made with medical-grade precision, they’re not quite ready for human trials or clinical use (yet!). Think of them as the groundwork for future breakthroughs, but for now, let’s keep them in the lab.
CLINICAL VERSATILITY
The CollGel™ Series is a versatile bioink designed for injectable stem cell delivery and bioprinted tissue engineering, currently designated for research use only (RUO).
With excellent cell encapsulation properties and injectability, CollGel™ is ideal for cell therapy applications, providing a supportive microenvironment for stem cells while maintaining high viability and retention at the target site. Its tunable formulation allows for the integration of functional molecules, such as growth factors or therapeutic agents, making it a versatile vehicle for drug delivery, regenerative therapies, and precision biofabrication.
By supporting customised hydrogel formulations for cell-based therapies, CollGel™ bridges preclinical research and translational medicine, paving the way for advanced regenerative treatments.
Room Temp. Restoration
Individual Vacuum Packed
STORAGE STABILITY
The CollGel™ Series bioinks, provided in a lyophilised (freeze-dried) format, ensure long-term stability without refrigeration, eliminating the need for cold-chain logistics. This design enhances transportation and storage efficiency, making CollGel™ highly suitable for applications in remote and resource-limited environments.
Its compact, lightweight, and shelf-stable format is particularly advantageous for space missions, where biomaterials must remain functional during extended storage and under extreme conditions. This capability positions CollGel™ as a promising biomaterial for future space healthcare and regenerative medicine applications.
FROM BENCH TO BED
The CollGel™ Series bioinks ensure batch-to-batch consistency, delivering reproducible results in preclinical research. Formulated with ISO 13485-certified medical-grade raw materials, CollGel™ is designed to support future clinical translation while remaining strictly for research applications.
As a medical-grade biomaterial, CollGel™ facilitates proof-of-concept studies and collaborative projects in regenerative medicine. With its reliable performance and scalability, it serves as a bridge between laboratory research and future clinical applications, paving the way for next-generation therapies.
We are actively working to make CollGel™ clinically ready, ensuring that our innovations can benefit researchers and clinicians, ultimately advancing translational medicine and patient care.
INKTEGRATION™ - SIMPLE IS POSSIBLE
[01]
FORMULATION DESIGN
COLLAGEN CONCENTRATION
[1X PBS/MEDIUM/H2O]
[02]
RECONSTITUTION
BACK AND FORTH [FULLY RECONSTITUTED]
WATCH UP YOUR THUMBS
[03]
COLLAGEN FIBRILLOGENESIS
KEEP 4°C ~12 HOURS - OVERNIGHT
[04]
READY TO PRINT
OR MIX WITH CELLS BEFORE PRINTING